Aplicación de métodos no lineales a las señales de magnetoencefalograma para valorar el daño cerebral en enfermos de deterioro cognitivo leve

  1. C. Gómez
  2. Jesús Poza Crespo
  3. J. Escudero
  4. Daniel Abásolo Baz
  5. A. Fernández
  6. Roberto Hornero Sánchez

ISSN: 1888-6116

Datum der Publikation: 2010

Ausgabe: 21

Nummer: 4

Seiten: 241-250

Art: Artikel

Andere Publikationen in: Trauma


Objective: Mild cognitive impairment (MCI) refers to the clinical state of subjects who suffer from some degree of cognitive deterioration but do not meet clinical criteria for dementia. Nowadays, magnetoencephalography (MEG) recordings are not used in MCI clinical diagnosis. Nevertheless, non-linear methods have demonstrated their usefulness for the analysis of brain recordings in this disease. Material and methods: We have examined the MEG background activity in 18 MCI patients and 24 elderly control subjects with five non-linear techniques: Lempel-Ziv complexity, Shannon spectral entropy, approximate entropy, sample entropy and detrended fluctuation analysis. Results: Our results suggest that MCI have an effect on the MEG background activity, producing a loss of complexity and irregularity on the recordings, and changes in the signals fluctuations. Conclusions: Our findings show the usefulness of non-linear measures to detect changes in the dynamical behaviour of brains injured by the development of MCI. Nevertheless, this study is only a first step for the use of non-linear analysis in the MCI diagnosis and further investigations are needed to confirm our results