Avances en la base genética de la enfermedad celíaca en población española

  1. Dema Jiménez, Barbara-Isabel
Supervised by:
  1. M. Concepcion Nuñez Pardo de Vera Director
  2. Elena Urcelay García Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 24 March 2010

Committee:
  1. Mónica de la Fuente del Rey Chair
  2. Edgar Fernández Malavé Secretary
  3. Elena García Arias Salgado Committee member
  4. Nora Viviana Butta Coll Committee member
  5. Josefa Blanco Rodríguez Committee member

Type: Thesis

Teseo: 112171 DIALNET lock_openDocta Complutense editor

Sustainable development goals

Abstract

Celiac disease (CD) is a chronic inflammatory intestinal disease triggered by the ingestion of prolamins from wheat, rye and barley in genetically susceptible individuals. CD is a genetically complex disease with several genes involved but also interactions among them and with environmental factors. The aim of this work is the search of new genetic factors that could contribute to CD susceptibility. We performed case-control and familial association studies, which are the most followed and successful strategies to detect genetic susceptibility factors in complex diseases.