Functional players in celiac diseaseidentification and genetic association/partehartzaile funtzionalak eritasun zeliakoan: identifikazioa eta asoziazio genetikoa

  1. CASTELLANOS RUBIO, AINARA
Zuzendaria:
  1. Luis Castaño González Zuzendaria
  2. José Ramón Bilbao Catalá Zuzendaria

Defentsa unibertsitatea: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 2010(e)ko urria-(a)k 22

Epaimahaia:
  1. Feliciano Jesús Ramos Fuentes Presidentea
  2. Jose Antonio Rodríguez Pérez Idazkaria
  3. Eduardo Arranz Sanz Kidea
  4. Katri Lindfors Kidea
  5. Mauro D' Amato Kidea

Mota: Tesia

Teseo: 300828 DIALNET lock_openTESEO editor

Laburpena

Gluten sensitive enteropathy or celiac disease (CD) is a chronic, inflammatory disorder characterized by flattened villi on the small bowel mucosa, caused by intolerance to ingested gluten in wheat, rye and barley that develops in genetically susceptible individuals. The main genetic factors associated with celiac disease are MHC class II genes that encode HLA-DQ2 and HLA-DQ8 molecules. However, HLA genes are necessary but not suffient to develop CD and during the last years, a great effort has been done in order to find additional genetic susceptibility determinants in CD, and approaches include genetic linkage studies, candidate gene association studies (positional or functional candidates) and more recently genome-wide association (GWA) studies. In order to dissect the genetics of this complex autoimmune disease, the current project has focused on the search of functional players in celiac disease using as a basis whole genome expression microarray