Genetic variants in the PPARD-PPARGC1A-NRF-TFAM mitochondriogenesis pathway are neither associated with muscle characteristics nor physical performance in elderly.

Referencias bibliográficas

• Attia, J.; Ioannidis, J. P.; Thakkinstian, A.; McEvoy, M.; Scott, R. J.; Minelli, C.; . . .
• Guyatt, G. (2009). How to use an article about genetic association: B: Are the results of the study valid? JAMA-Journal of the American Medical Association, 301(2), 191-197. http://dx.doi.org/10.1001/jama.2008.946
• Baztán, J. J.; Pérez del Molino, J.; Alarcón, T.; San Cristóbal, E.; Izquierdo, G., & Manzarbeitia, J. (1993). Índice de Barthel: Instrumento válido para la valoración funcional de pacientes con enfermedad cerebrovascular. Revista Española de Geriatría y Gerontología, 128, 32-40.
• Berger, J., & Moller, D. E. (2002). The mechanisms of action of PPARs. Annual review of medicine, 53, 409-435. http://dx.doi.org/10.1146/annurev.med.53.082901.104018
• Chanock, S.J.; Manolio, T.; Boehnke, M.; Boerwinkle, E.; Hunter, D.J.; Thomas, G.; . . . Collins, F.S. (2007) Replicating genotype-phenotype associations. Nature, 447(7145):655–660. http://dx.doi.org/10.1038/447655a
• Collin, C.; Wade, D. T.; Davies, S., & Horne, V. (1988). The Barthel ADL Index: a reliability study. International Disabilility Studies, 10(2), 61-63.
• De Abajo, S.; Larriba, R., & Marquez, S. (2001). Validity and reliability of the Yale Physical Activity Survey in Spanish elderly. Journal of Sports Medicine and Physical Fitness, 41(4), 479-485.
• Dipietro, L.; Caspersen, C. J.; Ostfeld, A. M., & Nadel, E. R. (1993). A survey for assessing physical activity among older adults. Medicine & Science in Sports & Exercise, 25(5), 628-642.
• Fannin, S. W.; Lesnefsky, E. J.; Slabe, T. J.; Hassan, M. O., & Hoppel, C. L. (1999). Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria. Archives of biochemistry and biophysics, 372(2), 399-407. Http://dx.doi.org/10.1006/abbi.1999.1508
• Fitzmaurice, G. (2002). Statistical methods for assessing agreement. Nutrition, 18(7-8), 694-696.
• Flueck, M.; Eyeang-Bekale, N.; Heraud, A.; Girard, A.; Gimpl, M.; Seynnes, O. R.; . . . Narici, M. (2011). Load-sensitive adhesion factor expression in the elderly with skiing: relation to fiber type and muscle strength. Scandinavian Journal of Medicine & Science in Sports, 21 Suppl 1, 29-38. http://dx.doi.org/10.1111/j.1600-0838.2011.01339.x
• Garatachea, N.; Fiuza-Luces, C.; Torres-Luque, G.; Yvert, T.; Santiago, C.; GomezGallego, F.; . . . Lucia, A. (2011). Single and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians. European Journal of Applied Physiology. http://dx.doi.org/10.1007/s00421-011-2217-4
• Garesse, R., & Vallejo, C. G. (2001). Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes. Gene, 263(1-2), 1-16.
• Gotshalk, L. A.; Volek, J. S.; Staron, R. S.; Denegar, C. R.; Hagerman, F. C., & Kraemer, W. J. (2002). Creatine supplementation improves muscular performance in older men. Medicine & Science in Sports & Exercise, 34(3), 537-543.
• Harriss, D. J., & Atkinson, G. (2011). Update--Ethical standards in sport and exercise science research. International journal of sports medicine, 32(11), 819-821. http://dx.doi.org/10.1055/s-0031-1287829
• Hood, D. A. (2009). Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle. Applied Physiology, Nutrition, and Metabolism, 34(3), 465-472.
• Jones, C. J.; Rikli, R. E., & Beam, W. C. (1999). A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Research Quarterly for Exercise & Sport, 70(2), 113-119.
• Kanki, T.; Ohgaki, K.; Gaspari, M.; Gustafsson, C. M.; Fukuoh, A.; Sasaki, N.; . . . Kang, D. (2004). Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA. Molecular and cellular biology, 24(22), 9823-9834. http://dx.doi.org/10.1128/MCB.24.22.9823-9834.2004
• Larsson, N. G.; Wang, J.; Wilhelmsson, H.; Oldfors, A.; Rustin, P.; Lewandoski, M.; . . . Clayton, D. A. (1998). Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nature genetics, 18(3), 231-236. http://dx.doi.org/10.1038/ng0398-231
• Lopez-Lluch, G.; Irusta, P. M.; Navas, P., & de Cabo, R. (2008). Mitochondrial biogenesis and healthy aging. Experimental gerontology, 43(9), 813-819. http://dx.doi.org/10.1016/j.exger.2008.06.014
• Mahoney, F. I., & Barthel, D. W. (1965). Functional Evaluation: The Barthel Index. Maryland State Medical Journal, 14, 61-65.
• Nair, K. S. (2005). Aging muscle. The American journal of clinical nutrition, 81(5), 953963.
• Rikli, R. E., & Jones, C. J. (1999). Development and validation of a funcional fitness test for comunityresiding older adults. Journal of Aging Physical Activity, 7(2), 129-161.
• Ruiz-Ruiz J, Mesa JL, Gutierrez A, Castillo MJ (2002) Hand sizeinfluences optimal grip span in women but not in men. Journal of Hand Surgery, 27(5):897–901.
• Puigserver, P.; Adelmant, G.; Wu, Z.; Fan, M.; Xu, J.; O´Malley, B. & Spiegelman, B.M. Activacion of PPARgamma coactivator-1 through transcription factor docking. Science (1999). 286(5443):1368-1371.
• Puigserver, P. & Spiegelman, B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocrine Reviews (2003). 24(1):78-90.
• Shah, V. O.; Scariano, J.; Waters, D.; Qualls, C.; Morgan, M.; Pickett, G.; . . . Raj, D. S. (2009). Mitochondrial DNA deletion and sarcopenia. Genetics in medicine : official journal of the American College of Medical Genetics, 11(3), 147-152. http://dx.doi.org/10.1097/GIM.0b013e31819307a2
• Short, K. R.; Bigelow, M. L.; Kahl, J.; Singh, R.; Coenen-Schimke, J.; Raghavakaimal, S., & Nair, K. S. (2005). Decline in skeletal muscle mitochondrial function with aging in humans. Proceedings of the National Academy of Sciences of the United States of America, 102(15), 5618-5623. http://dx.doi.org/10.1073/pnas.0501559102
• Stefan, N.; Thamer, C.; Staiger, H.; Machicao, F.; Machann, J.; Schick, F.; . . . Haring, H. U. (2007). Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. The Journal of clinical endocrinology and metabolism, 92(5), 18271833. http://dx.doi.org/10.1210/jc.2006-1785
• Sugiyama, S.; Takasawa, M.; Hayakawa, M., & Ozawa, T. (1993). Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochemistry and molecular biology international, 30(5), 937-944.
• Thamer, C.; Machann, J.; Stefan, N.; Schafer, S. A.; Machicao, F.; Staiger, H.; . . . Haring, H. U. (2008). Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study. The Journal of clinical endocrinology and metabolism, 93(4), 1497-1500. http://dx.doi.org/10.1210/jc.2007-1209
• Vieira, S., & Corrente, J. E. (2011). Statistical methods for assessing agreement between double readings of clinical measurements. Journal of applied oral science : revista FOB, 19(5), 488-492.
• Vina, J.; Gomez-Cabrera, M. C.; Borras, C.; Froio, T.; Sanchis-Gomar, F.; Martinez-Bello, V. E., & Pallardo, F. V. (2009a). Mitochondrial biogenesis in exercise and in ageing. Advanced Drug Delivery Reviews, 61(14), 1369-1374.
• Vina, J.; Gomez-Cabrera, M. C.; Borras, C., Froio, T.; Sanchis-Gomar, F.; Martinez-Bello, V. E., & Pallardo, F. V. (2009b). Mitochondrial biogenesis in exercise and in ageing. Advanced drug delivery reviews, 61(14), 1369-1374. http://dx.doi.org/10.1016/j.addr.2009.06.006
• Wisloff, U.; Najjar, S. M.; Ellingsen, O.; Haram, P. M.; Swoap, S.; Al-Share, Q.; . . . Britton, S. L. (2005). Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science, 307(5708), 418-420.
• Wu, Z.; Puigserver, P.; Andersson, U.; Zhang, C.; Adelmant, G.; Mootha, V.; . . . Spiegelman, B.M. (1999). Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell, 98(1): 115-124.