Antecedentes perinatales y familiares en trastornos del espectro autista

  1. C. Domínguez Martín
  2. M. Brezmes Raposo
  3. C. Ochoa Sangrador
  4. M. Muñoyerro Sesmero
  5. C. González González
  6. M.F. Muñoz Moreno
Journal:
Revista de Psiquiatría Infanto-Juvenil

ISSN: 2660-7271,  1130-9512

Year of publication: 2015

Volume: 32

Issue: 3

Pages: 139-144

Type: Article

DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Revista de Psiquiatría Infanto-Juvenil

Abstract

Abstract Objective: To evaluate perinatal risk factors and parental characteristics in Autistic Spectrum Disorder (ASD). Method: Obstetric conditions and parental characteristics were compared between ASD and two control groups without ASD (one from emergency room and the other from psychiatry outpatient service and day-care hospital). Result: There were 20 patients in each group (17 boys and 3 girls), ages 6-18. The pervasive developmental disorder (PDD) case group had 4 Autistic, 11 Asperger ́s and 5 pervasive developmental disorder not otherwise specified (PDD-NOS). Assisted pregnancies in 20% of PDD case group and 5% of control group B. All control group A were spontaneous pregnancies (p= 0.039). Statistically significant differences in maternal diseases between PDD case and control group A (p=0.041). Delivered by cesarean section in 65% of PDD case group, against 35% control A group and 25% of control B group (p=0.039). Statistically significant differences in family and maternal psychiatry history between three groups (p=0.008 and p=0.001). ASD has been diagnosed in 30% of relatives in PDD case group and none in control groups (p=0.01). Conclusion: This study found some obstetric and parental risk factors related with ASD, according to the literature. Future research should attempt to identify obstetric factors and understand their relationship with different genetically influenced processes in early development.

Bibliographic References

  • Penrose LS. (1976). The effects of change in maternal age distribution upon the incidence of mongolism. J Ment Defic Res; 11: 54-7.
  • Durkin MV et al. (1976). Analysis of etiologic factors in cerebral palsy with severe mental retardation, I: analysis of gestational, parturitional and neonatal data. Eur J Pediatr;123: 67-81.
  • Croen LA et al (2001). The epidemiology of mental retardation of unknown cause. Pediatr; 107:E86.
  • Malaspina D et al (2001). Advancing paternal age and risk of schizophrenia. Arch Gen Psychiatry; 58: 361-7.
  • Cannon M et al (2002). Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry; 159:1080-92.
  • Moster D. et al (2008). Long-term medical and social consequences of preterm birth. N Engl J Med; 359: 262-73.
  • Aram DM et al. (1991). Very-low-birthweight children and speech and language development. J Speech Hear Res; 34: 1169-79.
  • Veen S et al (1991). Impairments, disabilities, and handicaps of very preterm and very-lowbirthweight infants at five years of age. The Collaborative Project on Preterm and Small for Gestational Age Infants (POPS) in The Netherlands. Lancet; 338:33-6.
  • Hack M et al (1994). School-age outcomes in children with birth weights under 750 g. N Engl J Med; 331:753-9.
  • Pharoah PO et al (1994). Prevalence of behavior disorders in low birthweight infants. Arch Dis Child; 70:271-4.
  • Schothorst PF, van Engeland H. (1996). Long-term behavioral sequelae of prematurity. J Am Acad Child Adolesc Psychiatry; 35:175-83.
  • Glasson EJ et al (2004). Perinatal factors and the development of autism: A population study. Arch Gen Psychiatry; 61:618–27.
  • Larsson HJ et al (2005). Risk factors for autism: Perinatal factors, parental psychiatric history, and socioeconomic status. Am J of Epidemiol; 161: 916–25.
  • Bchmayer S et al (2009). Can Association Between Preterm Birth and Autism be Explained by Maternal or Neonatal Morbidity? Pediatr; 124;e817-25.
  • Gardener H et al (2011). Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Metaanalysis. Pediatr; 128;344-55.
  • Bolton PF et al (1997). Obstetric complications in autism: Consequences or causes of the condition? J Am Acad Child Adolesc Psychiatry; 36:272–81.
  • Kolevzon A, Gross R, Reichenberg A. (2007). Prenatal and perinatal risk factors for autism: a review and integration of findings. Arch Pediatr Adolesc Med; 161:326-33.
  • Bailey A et al (1996). Autism: Towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. J Child Psychol Psychiatry; 37: 89–126.
Data source: Dialnet