Valor pronóstico de la fórmula HUGE en el seguimiento de la enfermedad renal en ancianos

Abstract

Introduction: Hematocrit, urea and gender (HUGE) formula is designed to screen for kidney failure. It is considered that if the HUGE value is greater than 0, the patient was a carrier of kidney failure. This study examines the usefulness of the formula HUGE in prognosis of renal disease (acute renal failure [ARF], renal disease progression and mortality). Patients and methods: HUGE formula was calculated at baseline in 67 elderly patients with a mean age of 82.22 ± 6.67 years (range 69-97), 25 males (37.3%) and 42 women (62,7%), were recruited at random in our Geriatrics and Nephrology Departments in year 2006. After 36 months of follow-up were analyzed prognosis studied and its association with the basal HUGE value. Results: At baseline, the mean value HUGE formula was -0,34 ± 4.53 (range -5.5-19.43) and estimated glomerular filtration rate MDRD-4 was 51.92 ± 17 ml/min/1.73m2 (range 19.18-86.7). With HUGE formula at baseline, only 21 patients (13 males and 8 females) (31.3%) had a value greater than 0. At follow-up of 67 elders, 18 patients died. Of the 49 patients who were still alive at 36 months, 12 had an episode of ARF. Patients with HUGE > 0 were significantly more ARF and mortality (p = 0,001), higher serum creatinine increase at 36 months (p = 0,003) and decreased MDRD of 2.10 ml/min/year versus 0, 99 ml/min/year in patients with HUGE <0 (not significant). Conclusions: HUGE formula could help to identify the group of patients with renal insufficiency true and therefore at risk of prognosis of renal disease.