Función ejecutiva, lenguaje pragmático y perfiles psicopatológicos según la CBCL en niños con trastornos del neurodesarrollo y antecedentes familiares de esquizofrenia

  1. M.A. Parrilla Escobar 1
  2. S. Cerezo Corredera 1
  3. B. García Díez 1
  4. C. de Andrés Lobo 1
  5. C. de Cáceres Riol 1
  6. M.A. Maniega Rubio 1
  7. V. Molina Rodríguez 1
  1. 1 ervicio de Psiquiatría. Sección de Psiquiatría Infanto-Juvenil. Hospital Clínico Universitario deValladolid, España.
Zeitschrift:
Revista de Psiquiatría Infanto-Juvenil

ISSN: 2660-7271 1130-9512

Datum der Publikation: 2020

Ausgabe: 37

Nummer: 1

Seiten: 5-16

Art: Artikel

DOI: 10.31766/REVPSIJ.V37N1A2 DIALNET GOOGLE SCHOLAR lock_openOpen Access editor

Andere Publikationen in: Revista de Psiquiatría Infanto-Juvenil

Ziele für nachhaltige Entwicklung

Zusammenfassung

The CBCL is a standardized form that parents fill out to describe their children ́s behavioral and emotional problems. Previous studies have suggested that two subscales, “withdrawal-depressed” and mainly “thought problems” may have utility as a psychosis risk screening measure in youth. Executive function and higher-order language dysfunctions have been postulated as potential endophenotypes for schizophrenia. Objectives: To identify by means of the two CBCL subscales mentioned above, a group of children and adolescents with higher ratings amongst those patients attending an outpatient psychiatric clinic, who present a neurodevelopmental disorder and a family history of schizophrenia Material and methods: Parents filled out CBCL, CCC-Childrens Communication Checklist- (evaluates pragmatic language) and BRIEF-2 (Behavior Rating Inventory of Executive Function). Results: Twenty-one children were included (16 males; 5 females). Mean age 11,4 y/o. Main diagnoses were ADHD (66,7%), Learning Disorder (9,5%) and ASD (9,5%). CBCL subscales “withdrawn-depressed” and “thought problems” discriminated two groups. One with higher ratings (above Pc70) showing the presence of symptoms (n=11) and the other with lower ratings (below Pc70) indicating symptom absence (n=10). The first group showed more pragmatic language difficulties as well as poorer executive function. Conclusions: A more comprehensive dimensional evaluation of the psychopathology of children with neurodevelopmental disorders and family history of schizophrenia, by means of CBCL, may provide a better description of premorbid difficulties, helping to identify more vulnerable cases for long term follow up and early intervention.

Bibliographische Referenzen

  • Meyer-Lindenberg A. Studying Developmental Psychopathology Related to Psychotic Disorders - Challenges and Paradigms in Human Studies. Schizophr Bull. 2017;43(6):1169–1171. https://doi.org/10.1093/schbul/sbx129
  • Carpenter WT, Strauss JS. Developmental Interactive Framework for Psychotic Disorders. Schizophr Bull. 2017;43(6):1143–1144. https://doi.org/10.1093/schbul/sbx123
  • Murray RM, Bhavsar V, Tripoli G, Howes O. 30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed into the Developmental Risk Factor Model of Psychosis. Schizophr Bull. 2017;43(6):1190–1196. https://doi.org/10.1093/schbul/sbx121
  • Parellada M, Gomez-Vallejo S, Burdeus M, Arango C. Developmental Differences between Schizophrenia and Bipolar Disorder. Schizophr Bull. 2017;43(6):1176–1189. https://doi.org/10.1093/schbul/sbx126
  • Rodríguez Sacristán J (ed. . Psicopatología del niño y del adolescente. Tomo 2. 2a Edición. Rodríguez-Sacristán J, editor. Sevilla: Universidad de Sevilla. Secretariado de publicaciones; 1998. 1027 p. ISBN: 84-472-0277-1
  • Zwicker A, MacKenzie LE, Drobinin V, Howes Vallis E, Patterson VC, Stephens M, et al. Basic symptoms in offspring of parents with mood and psychotic disorders. BJPsych Open. 2019;5(4):1–7. https://doi.org/10.1192/bjo.2019.40
  • Díaz-Caneja CM, Morón-Nozaleda MG, Vicente-Moreno RP, Rodríguez-Toscano E, Pina-Camacho L, de la Serna E, et al. Temperament in child and adolescent offspring of patients with schizophrenia and bipolar disorder. Eur Child Adolesc Psychiatry. 2018;27(11):1459–1471. https://doi.org/10.1007/s00787-018-1135-y
  • Thompson E, Kline E, Reeves G, Pitts SC, Schiffman J. Identifying youth at risk for psychosis using the Behavior Assessment System for Children, Second Edition. Schizophr Res . 2013;151(1–3):238–244. http://dx.doi.org/10.1016/j.schres.2013.09.022
  • Achenbach TM, Ruffle TM. The child behavior checklist and related forms for assessing behavioral/emotional problems and competencies. Pediatr Rev. 2000;21(8):265–271. https://doi.org/10.1542/pir.21-8-265
  • Simeonova DI, Nguyen T, Walker EF. Psychosis risk screening in clinical high-risk adolescents: A longitudinal investigation using the Child Behavior Checklist. Schizophr Res . 2014 Oct ;159(1):7–13. http://www.ncbi.nlm.nih.gov/pubmed/25171857
  • Scott J, Martin G, Welham J, Bor W, Najman J, O’Callaghan M, et al. Psychopathology during childhood and adolescence predicts delusionallike experiences in adults: A 21-year birth cohort study. Am J Psychiatry. 2009;166(5):567–574. https://doi.org/10.1176/appi.ajp.2008.08081182
  • Welham J, Scott J, Williams G, Najman J, Bor W, O’Callaghan M, et al. Emotional and behavioural antecedents of young adults who screen positive for non-affective psychosis: a 21-year birth cohort study. Psychol Med . 2009 Apr 8;39(4):625–634. http://www.ncbi.nlm.nih.gov/pubmed/18606046
  • Jansen PR, Polderman TJC, Bolhuis K, van der Ende J, Jaddoe VWV, Verhulst FC, et al. Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population. J Child Psychol Psychiatry Allied Discip. 2018;59(1):39–47. https://doi.org/10.1111/jcpp.12759
  • Aydın E, Cansu Ülgen M, Tabo A, Devrim Balaban Ö, Ye-ilyurt S, Yumrukçal H. Executive function and genetic loading in nonpsychotic relatives of schizophrenia patients. Psychiatry Res. 2017;248:105–110. https://doi.org/10.1016/j.psychres.2016.12.027
  • Gutiérrez TS, Toscano ER, Llorente C, De E, Moreno C, Sugranyes G, et al. Neuropsychological , clinical and environmental predictors of severe mental disorders in offspring of patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2019;(0123456789). https://doi.org/10.1007/s00406-019-01044-7
  • Paweł-czyk A, Łojek E, Żurner N, Gawłowska-Sawosz M, Pawełczyk T. Higher-order language dysfunctions as a possible neurolinguistic endophenotype for schizophrenia: Evidence from patients and their unaffected first degree relatives. Psychiatry Res. 2018;267:63–72. https://doi.org/10.1016/j.psychres.2018.05.07
  • Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, et al. A Children’s Global Assessment Scale (CGAS). Arch Gen Psychiatry . 1983 Nov 1 ;40(11):1228. http://www.ncbi.nlm.nih.gov/pubmed/6639293
  • Baremos para CBCL 6-18(2001). Unitat d’Epidemiologia i de Diagnòstic en Psicopatologia del desenvolupament [Internet]. 2013. Available from: www.ued.uab.es
  • Bishop DVM. Development of the Children’s Communication Checklist (CCC): A method for assessing qualitative aspects of communicative impairment in children. J Child Psychol Psychiatry Allied Discip. 1998;39(6):879–891. https://www.ncbi.nlm.nih.gov/pubmed/9758196
  • Crespo-Eguílaz N, Magallón S, Sánchez-Carpintero R, Narbona J. La adaptación al castellano de la Children’s Communication Checklist permite detectar las dificultades en el uso pragmático del lenguaje y diferenciar subtipos clínicos. Rev Neurol. 2016;62(Supl 1):S49–57. https://doi.org/10.33588/rn.62S01.2015526
  • Mazza M, Di Michele V, Pollice R, Casacchia M, Roncone R. Pragmatic language and theory of mind deficits in people with schizophrenia and their relatives. Psychopathology. 2008;41(4):254–263. https://doi.org/10.1159/000128324
  • Christiani CJ, Jepsen JRM, Thorup A, Hemager N, Ellersgaard D, Spang KS, et al. Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7—A Population-Based Cohort Study. Schizophr Bull. 2019; https://doi.org/10.1093/schbul/sbz001
  • Sullivan SA, Hollen L, Wren Y, Thompson AD, Lewis G, Zammit S. A longitudinal investigation of childhood communication ability and adolescent psychotic experiences in a community sample. Vol. 173, Schizophrenia Research. 2016. p. 54–61. https://doi.org/10.1016/j.schres.2016.03.005
  • Solomon M, Olsen E, Niendam T, Ragland JD, Yoon J, Minzenberg M, et al. From lumping to splitting and back again: atypical social and language development in individuals with clinical-high-risk for psychosis, first episode schizophrenia, and autism spectrum disorders. Schizophr Res . 2011 Sep;131(1–3):146–151. https://linkinghub.elsevier.com/retrieve/pii/
  • Done DJ, Leinonen E. Pragmatic use of language by children who develop schizophrenia in adult life. Schizophr Res. 2013;147(1):181–186. http://dx.doi.org/10.1016/j.schres.2013.03.005
  • Clark K, Narr KL, O’Neill J, Levitt J, Siddarth P, Phillips O, et al. White matter integrity, language, and childhood onset schizophrenia. Schizophr Res. 2012 Jul;138(2–3):150–156. http://www.ncbi.nlm.nih.gov/pubmed/22405729
  • Bosco FM, Berardinelli L, Parola A. The ability of patients with schizophrenia to comprehend and produce sincere, deceitful, and ironic communicative intentions: The role of theory of mind and executive functions. Front Psychol. 2019;10(May):1–13. https://doi.org/10.3389/fpsyg.2019.00827
  • Radanovic M, de Sousa RT, Valiengo LL, Gattaz WF, Forlenza OV. Alteração formal do pensamento e prejuízo da linguagem na esquizofrenia. Arq Neuropsiquiatr. 2013;71(1):55–60. https://doi.org/10.1590/s0004-282x2012005000015
  • Parsons L, Cordier R, Munro N, Joosten A, Speyer R. A systematic review of pragmatic language interventions for children with autism spectrum disorder. PLoS ONE. 2017; 12: 1–37. https://doi.org/10.1371/journal.pone.0172242
  • Wilkes-Gillan S, Munro N, Cordier R, Cantrill A, Pearce W. Pragmatic Language Outcomes of Children With Attention Deficit Hyperactivity Disorder After Therapist- and Parent-Delivered Play-Based Interventions: Two One-Group Pretest-Posttest Studies With a Longitudinal Component. Am J Occup Ther . 2017 Jul 6;71(4):7104220030p1–10. http://ajot.aota.org/
  • Birkett P, Sigmundsson T, Sharma T, Toulopoulou T, Griffiths TD, Reveley A, et al. Executive function and genetic predisposition to schizophrenia - The Maudsley family study. Am J Med Genet Part B Neuropsychiatr Genet. 2008;147(3):285–293. https://doi.org/10.1002/ajmg.b.30594
  • Dickson H, Cullen AE, Jones R, Reichenberg A, Roberts RE, Hodgins S, et al. Trajectories of cognitive development during adolescence among youth at-risk for schizophrenia. J Child Psychol Psychiatry Allied Discip. 2018;59(11):1215–1224. https://doi.org/10.1111/jcpp.12912
  • Ziermans T, Swaab H, Stockmann A, de Bruin E, van Rijn S. Formal thought disorder and executive functioning in children and adolescents with autism spectrum disorder: Old leads and new avenues. J Autism Dev Disord. 2017;47(6):1756–1768. https://doi.org/10.1007/s10803-017-3104-6
  • de la Serna E, Sugranyes G, Sanchez-Gistau V, Rodriguez-Toscano E, Baeza I, Vila M, et al. Neuropsychological characteristics of child and adolescent offspring of patients with schizophrenia or bipolar disorder. Schizophr Res. 2017;183(2017):110–115. https://doi.org/10.1016/j.schres.2016.11.007
  • Treen Calvo D, Giménez-Donoso S, Setién-Suero E, Toll Privat A, Crespo-Facorro B, Ayesa Arriola R. Targeting recovery in first episode psychosis: The importance of neurocognition and premorbid adjustment in a 3-year longitudinal study. Schizophr Res . 2018;195(2018):320–326. https://doi.org/10.1016/j.schres.2017.08.032
  • Shuai L, Daley D, Wang YF, Zhang JS, Kong YT, Tan X, et al. Executive function training for children with attention deficit hyperactivity disorder. Chin Med J (Engl). 2017;130(5):549–558. https://doi.org/10.4103/0366-6999.200541
  • Seidman LJ, Nordentoft M. New Targets for Prevention of Schizophrenia: Is It Time for Interventions in the Premorbid Phase? Schizophr Bull. 2015;41(4):795–800. https://doi.org/10.1093/schbul/sbv050
  • Do KQ, Cuenod M, Hensch TK. Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia. Schizophr Bull. 2015;41(4):835–846. https://doi.org/10.1093/schbul/sbv065