Concentraciones de colesterol, α-tocoferol y retinoides en aceite de silicona tras su utilizaciσn como sustitutivo vítreo

  1. J.C. Pastor
  2. M.J. Del Nozal
  3. P Marinero
  4. O. Díez
Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2006

Volume: 81

Issue: 1

Pages: 13-19

Type: Article

DOI: 10.4321/S0365-66912006000100005 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Archivos de la Sociedad Española de Oftalmologia

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Abstract

Objective: To verify the existence of organic lipophylic compounds in silicone oil extracted from human eyes following its use for previous retinal detachment, and to determine the intraocular permanence time of these substances in the oil. Methods: Concentrations of retinoic acid, retinol, retinal, cholesterol and α-tocopherol were detected by HPLC in 23 samples of silicone oil extracted from patients with complicated retinal detachments. The time interval between the time of injection of the silicone oil and the subsequent assessment varied from 3 to 50 months (the permanence time). Results: All tested compounds were found in the samples, but these were most commonly cholesterol and less frequently α-tocopherol. There was an inverse relationship between retinoic acid concentration and age (p=0.023), and a direct relationship between cholesterol concentration and permanence time (p=0.0008) at least up to 20 months. Conclusions: These findings confirm that silicone oil is not an inert substance but is capable of extracting lipophylic compounds from the intraocular tissues. There is a clear linear elevation of cholesterol levels with increased intraocular permanence time. This finding could be used to further establish a safe permanence time for intraocular silicone oil used in ophthalmologic surgery. More studies with larger samples are warranted to evaluate this further.

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