Hipervitaminosis B12 y mortalidad a edades avanzadas

  1. García Rodríguez, Ana María
  2. Sánchez Velasco, Miguel José
  3. González Melgosa, Isabel
  4. Villaescusa Fulgencio, Cristina
  5. Alonso Díaz, Félix Antonio
  6. Sánchez Gómez, Esther
Atención familiar: Órgano de difusión científica del Departamento de Medicina Familiar

ISSN: 1405-8871

Year of publication: 2021

Volume: 28

Issue: 1

Pages: 26-32

Type: Article

DOI: 10.22201/FM.14058871P.2021.1.77657 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Atención familiar: Órgano de difusión científica del Departamento de Medicina Familiar


Objective: to study the cause of death and associated comorbidities in patients with hypervitaminosis B12 and with altered laboratory parameters. Methods: cross-sectional study. Information was taken from 156 dead people diagnosed with hypervitaminosis B12 from 2016 to 2019, patients with previous tumors were excluded. B12 product was analyzed by crp index (vitamin B12/C-reactive protein Index). Sex, age, day and cause of exitus, associated pathologies and concomitant analytical alterations were taken as study variables. The results were expressed in percentages and means; the crp was expressed in or and 95% ci. Results: a mortality of 10.5% was detected, average age 78.42, B12 1441 pg/ml and mean of 158 days at the moment of death. Vitamin B12 value was related to age and sex (p=0.025). The presence of neoplasms was 37%; of which digestive tumors were presented in 29.7% and metastases in 21.2%; with respect to the presence of infectious causes was in 15%, of which pneumonia was manifested in 58%, sepsis in 48%; and cardiac complications were 13.6%. The parameters with the greatest alteration were ggt (59%), ferritin (47.4%) and af (41.7%). The crp section >40,000 occurred in 57% of the patients with a distance to death within one month. Conclusions: in presence of hypervitaminosis B12, men die before women, mainly due to digestive tumors, 50% before six months; men present high levels of ggt and ferritin in one of every two cases.