Seizures and COVID-19: Results from the Spanish Society of Neurology’s COVID-19 registry

  1. Fernández, Santiago Fernández 1
  2. Pérez Sánchez, Javier Ricardo 2
  3. Pérez, Guillermo Hernández 3
  4. Pérez, María Rabasa 4
  5. Castro, Cristina Guijarro 56
  6. García-Azorín, David
  7. Ezpeleta, David 7
  1. 1 Hospital Clinic Barcelona
    info

    Hospital Clinic Barcelona

    Barcelona, España

    ROR https://ror.org/02a2kzf50

  2. 2 Hospital General Universitario Gregorio Marañón
    info

    Hospital General Universitario Gregorio Marañón

    Madrid, España

    ROR https://ror.org/0111es613

  3. 3 Hospital Universitari de Bellvitge
    info

    Hospital Universitari de Bellvitge

    l'Hospitalet de Llobregat, España

    ROR https://ror.org/00epner96

  4. 4 Hospital de Fuenlabrada
    info

    Hospital de Fuenlabrada

    Fuenlabrada, España

    ROR https://ror.org/04scbtr44

  5. 5 Hospital Universitario HM Puerta del Sur
    info

    Hospital Universitario HM Puerta del Sur

    Móstoles, España

    ROR https://ror.org/03rk6g530

  6. 6 Hospital Universitario de Valladolid
    info

    Hospital Universitario de Valladolid

    Valladolid, España

    ROR https://ror.org/04fffmj41

  7. 7 Hospital Universitario Quirónsalud Madrid
    info

    Hospital Universitario Quirónsalud Madrid

    Madrid, España

    ROR https://ror.org/018q88z15

Mostrar afiliaciones +
Revista:
Journal of Clinical Neuroscience

ISSN: 0967-5868

Año de publicación: 2022

Volumen: 101

Páginas: 112-117

Tipo: Artículo

DOI: 10.1016/J.JOCN.2022.05.013 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Journal of Clinical Neuroscience

Resumen

We describe a series of patients with COVID-19 who presented with seizures, reported in the Spanish Society of Neurology’s COVID-19 Registry.This observational, descriptive, multicentre, registry-based study includes patients with confirmed COVID-19 who experienced seizures during active infection. We describe the clinical presentation of COVID-19, seizures, and results of complementary tests. We also describe the suspected aetiology of the seizures.Of 232 reported cases, 26 (11.2%) presented with seizures; 7 of these patients (26.9%) had prior history of epilepsy, whereas the remaining 19 (73.1%) had no history of seizures. In most cases, seizures presented on days 0 and 7 after onset of COVID-19. By seizure type, 8 patients (30.7%) presented generalised tonic-clonic seizures, 7 (26.9%) status epilepticus, 8 (30.7%) focal impaired-awareness seizures, and 4 (11.7%) secondary generalised seizures. Six patients (23.1%) also presented other neurological symptoms, including altered mental status and decreased level of consciousness. Predisposing factors for seizures (eg, dementia, tumour, cerebrovascular disease) were observed in 10 of the 19 patients with no prior history of epilepsy (52.6%).Patients with COVID-19 may present with seizures over the course of the disease, either alone or in the context of encephalopathy. Seizures may present in patients with no prior history of epilepsy; however, most of these patients present predisposing factors.

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