Electro and magnetically active polymer-based hybrid microenvironments for muscle tissue engineering

  1. DA COSTA HERMENEGILDO, BRUNO FILIPE
Dirigida por:
  1. Leyre Pérez Álvarez Director/a
  2. Senén Lanceros Méndez Director/a

Universidad de defensa: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 23 de marzo de 2022

Tribunal:
  1. José Carlos Rodríguez Cabello Presidente
  2. Leire Ruiz Rubio Secretario/a
  3. José Luis Vilas Vilela Vocal
  4. Silvia Barbosa Fernández Vocal
  5. Pedro Ribeiro Vocal

Tipo: Tesis

Teseo: 157564 DIALNET lock_openADDI editor

Resumen

An arrangement of cells in an adequate support has been shown to be the best way to mimic the natural microenvironment of tissues. Polymer structures have become the most suitable materials to create this support structure due to their tailorable properties and multifunctional properties. In fact, electro- and magnetoactive polymer based materials are increasingly being used to develop active microenvironments for cell stimulation.This work focuses on the study and development of polymer-based hybrid materials, functionalized with ionic liquids or magnetoelectric particles, to be used as scaffolds for the treatment of tissue injuries, defects and degenerative diseases, using concepts and technologies from the fields of tissue engineering, nanotechnology, physics, chemistry and biology.Various polymer materials and morphologies were processed and characterized, with and without either ionic liquids or magnetoelectric particles. They were tested in in-vitro conditions, to evaluate any possible toxic effects, and when relevant, their mechanical properties and degradability were assessed as well.