Relationship among angiotensin-converting enzyme polymorphism, cardiovascular risk, and osteoporotic fractures

  1. Briongos Figuero, Laisa Socorro 1
  2. Cuadrado Medina, Francisca 1
  3. Abad Manteca, Laura 1
  4. Vega Tejedor, Gemma 1
  5. Pineda Alonso, Mónica 1
  6. Pérez Castrillón, José Luis 1
  1. 1 Hospital Universitario Pío del Río Hortega

    Hospital Universitario Pío del Río Hortega

    Valladolid, España


European Journal of Rheumatology

ISSN: 2147-9720 2148-4279

Year of publication: 2016

Volume: 3

Issue: 1

Pages: 10-12

Type: Article

DOI: 10.5152/EURJRHEUM.2015.150040 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: European Journal of Rheumatology


Objective: Angiotensin-converting enzyme (ACE) has been related to cardiovascular physiology and bone remodeling. Our aim was to assess the relationship among ACE polymorphisms, cardiovascular risk, and osteoporotic fractures.Material and methods: We prospectively enrolled 71 patients with hypertension from 2001 to 2014. Sociodemographic and medical data were collected. Comorbidity was evaluated with Charlson index. Densitometric studies on lumbar spine were performed. ACE polymorphism was analyzed by polymerase chain reaction. Data were analyzed using SPSS 15.0 (p value <0.05).Results: Homozygous deletion (DD) genotype was described in 32.4% of patients, homozygous insertion (II) in 19.7%, and heterozygous insertion/deletion (ID) in 47.9%. On stratifying data by ACE polymorphism, we observed that DD carriers demonstrated neither greater cardiovascular risk factors (30.4% vs. 33.3%, p=0.4) and higher comorbidity (34.8% vs. 22.9%, p=0.3) nor higher osteoporotic fracture incidence (17.4% vs. 16.8%, p=0.9). In women, no significant differences were observed between DD homozygous individuals and ID+II subjects.Conclusion: It is unclear whether DD genotype is an independent risk factor for cardiovascular disease. In contrast to our expectations, we found no relationship among the DD genotype, cardiovascular risk, and osteoporotic fracture incidence.