Prolinamides as Asymmetric Organocatalysts

  1. Pedrosa Sáez, Rafael
  2. Andrés García, José María
Libro:
Sustainable Catalysis: Without Metals or Other Endangered Elements

Editorial: Royal Society of Chemistry

ISBN: 978-1-78262-209-3

Año de publicación: 2015

Páginas: 120-139

Tipo: Capítulo de Libro

DOI: 10.1039/9781782622093-00120 GOOGLE SCHOLAR lock_openUVADOC editor

Resumen

Prolinamides are valuable organocatalysts for enantioselective transformations that occur by activation of the nucleophile by enamine formation. Different substituents can be appended on the nitrogen atom of the carboxamide, which allow for the modulation of the catalytic properties. In that way, the acidity, the hydrogen donor properties, the hydrophobicity, or the chiral environment can be modified, in a few steps, starting from easily available proline.

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