ChemInform Abstract: Comparative Reactivity of 3-Methyl-5-phenylisoxazole and 3-Methyl-5- phenylisothiazole Against Electrophilic Compounds.
- ALBEROLA, A. 1
- CALVO, L. 1
- RODRIGUEZ RODRIGUEZ, M. T. 1
- SANUDO, M. C. 1
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1
Universidad de Valladolid
info
ISSN: 0931-7597
Año de publicación: 2010
Volumen: 26
Número: 36
Páginas: no-no
Tipo: Artículo
Otras publicaciones en: ChemInform
Resumen
Reactionof 3-methyl-5-phenylisoxazole (I) with electrophiles in the presence of BuLi givesrise to both reaction products at the C-4 position (cf. (III), (VI)) and the C-3 methyl group (cf. (IV), (VII)). By use of lithium isopropyl(cyclohexyl)amide (LICA) as base, regioselective reactions at the C-3 methyl group are observed. Reactions of 3-methyl-5-phenylisothiazole (VIII) furnish only products at the C-3-methyl group, in general.
Referencias bibliográficas
- ALBEROLA, (1995), J. Heterocycl. Chem., 32, pp. 537, 10.1002/jhet.5570320228