Los genes brca1 y brca2. Estudio molecular

1. A. San Miguel
2. I. Gonzalez Blanco
3. J.A. Minguéz Pargas
4. L. Martín Rodríguez
5. R. García Iglesias
6. N. Alonso
7. F.J. Martín Gil

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Andere Publikationen in: Revista Electrónica de Biomedicina

Zusammenfassung

In the last years, numerous studies were made to establish the hereditary predisposition to the cancer and the mutationals alterations at level of genes susceptible to originate breast and ovarian cancers. In 1994 genes BRCA1 (Breast Cancer Gene 1) and BRCA2 were identified (Breast Cancer Gene 2) as susceptible of both of breast and ovarian cancers. At the present time, it is knows that the mutations in BRCA 1 and BRCA 2 are far from explaining the totality of the cases of breast cancer and/or ovary, and although mutationals alterations in other genes like CHEK2, TP53 and PTEN, the BRCA1 and BRCA2 are postulated, they continue having his importance and utility in the valuation of the risk of hereditary predisposition. Correlations between both BRCA1 and BRCA2 levels with tumour grade metastasis and prognostic accuracy. Between 15 and 85% of the carrying women of mutation BRCA 1 or BRCA 2 have risk of developing a cancer of breast and between 10 and 60% to develop an ovarian cancer.

Fuente de los datos: Dialnet