Factores pronósticos del cáncer de mama y oncogen her2/neu
- A. San Miguel
- I. Gonzalez Blanco
- R. García Iglesias
- N. Alonso
- A.B. Rodríguez Bujez
- E.M. Martin Medrano
- F.J. Martín Gil
ISSN: 1697-090X
Any de publicació: 2006
Número: 2
Pàgines: 72-88
Tipus: Article
Altres publicacions en: Revista Electrónica de Biomedicina
Resum
The breast cancer constitutes the main cause of death by cancer in women of our country. In spite of the efforts directed in campaigns of precocious detection, the incidence continues increasing in a 1% approximately per year and the rate of mortality stay constant. Therefore it is of great importance to consolidate efforts directed towards the development and use of therapeutic and diagnostic methods. The development of neoplasia is directly related to successive genetic mutations in which cellular oncogenes are involved. It is known that in case of breast cancer the Her2/neu oncogene (Human epidermal growth receptor-2 factor) is amplified and/or overexpressed in approximately a 30% of the cases. The knowledge of a positive result for Her2/neu overexpression has an important value in prognosis as it is associated to a greater aggressiveness of the disease. Also, this gene can be an answer marker to certain treatments like trastuzumab.