Valoración inmunológica en la detección de la infección perioperatoria en pacientes intervenidos por cáncer de colon

  1. Francisca Moreno Racionero 1
  2. María Bedate Núñez 1
  3. Beatriz De Andrés Asenjo 1
  4. Juan Beltrán de Heredia y Rentería 1
  5. Ana Patricia Legido Morán 1
  6. Jesús Francisco Bermejo Martín 1
  7. José Máximo Rabadan Jimenez 1
  1. 1 Complejo Asistencial Universitario de Palencia
    info

    Complejo Asistencial Universitario de Palencia

    Palencia, España

    ROR https://ror.org/02atpex25

Revista:
Anales de la Real Academia de Medicina y Cirugía de Valladolid

ISSN: 0210-6523

Año de publicación: 2020

Número: 56

Páginas: 345-378

Tipo: Artículo

DOI: 10.24197/ARAMCV.56.2020.345-378 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Otras publicaciones en: Anales de la Real Academia de Medicina y Cirugía de Valladolid

Resumen

Objetivos: Evaluar la utilidad de la cuantificación en la concentración de leucocitos y subpoblaciones linfocitarias en sangre para identificar la presencia de fuga anastomótica, en pacientes intervenidos de cáncer de colon, incluso antes de la aparición de síntomas clínicos. Método: Estudio prospectivo observacional que consiste en extraer diferentes muestras de sangre el día previo a la intervención, a las 24 horas, 72 horas y 120 horas post-cirugía, para determinar las subpoblaciones linfocitarias en pacientes que requirieron una intervención quirúrgica programada de cáncer de colon. Resultados: Se analizaron 62 enfermos intervenidos de cáncer de colon durante un periodo de 22 meses, de los cuales 7 pacientes presentaron fuga anastomótica, observándose que presentar ≤ 379 células/mm3 de LTCD4 a las 72 horas de la cirugía indicaba un riesgo de fuga anastomótica de 19,7 veces más respecto de aquellos que tienen cifras superiores (p=0,025). Conclusión: La monitorización de las subpoblaciones linfocitarias y más concretamente de los LTCD4 durante el periodo perioperatorio en el cáncer de colon puede servir para detectar de manera precoz la presencia de fuga anastomótica.

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Fuente de los datos: Dialnet