JAIME
SANTO DOMINGO MAYORAL
INVESTIGADOR DISTINGUIDO SENIOR
![Foto de JAIME](/img/nophoto.png)
![Foto de Nestlé Health Science](/img/noimage_org.png)
Nestlé Health Science
Lausanne, SuizaPublicacions en col·laboració amb investigadors/es de Nestlé Health Science (17)
2023
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SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells
Journal of Cell Science, Vol. 136, Núm. 8
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The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state
Redox Biology, Vol. 64
2022
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Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity
Journal of Biological Chemistry, Vol. 298, Núm. 3
2021
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Mitochondrial ion channels in pancreatic β-cells: Novel pharmacological targets for the treatment of Type 2 diabetes
British Journal of Pharmacology, Vol. 178, Núm. 10, pp. 2077-2095
2020
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Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
Diabetologia, Vol. 63, Núm. 12, pp. 2628-2640
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Protein Lysine Acetylation: Grease or Sand in the Gears of β-Cell Mitochondria?
Journal of Molecular Biology, Vol. 432, Núm. 5, pp. 1446-1460
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Targeting mitochondrial calcium uptake with the natural flavonol kaempferol, to promote metabolism/secretion coupling in pancreatic β-cells
Nutrients, Vol. 12, Núm. 2
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Targeting mitochondrial ion channels in Type 2 diabetes
Future Medicinal Chemistry, Vol. 12, Núm. 17, pp. 1525-1527
2019
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Cellular stress is a prerequisite for glucose-induced mitochondrial matrix alkalinization in pancreatic β-cells
Molecular and Cellular Endocrinology, Vol. 481, pp. 71-83
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Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release from the endoplasmic reticulum by AMP-activated kinase modulators
Cell Calcium, Vol. 77, pp. 68-76
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The plant product quinic acid activates Ca2+-dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells
British Journal of Pharmacology, Vol. 176, Núm. 17, pp. 3250-3263
2017
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A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells
Journal of Cell Science, Vol. 130, Núm. 11, pp. 1929-1939
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Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation
Scientific Reports, Vol. 7
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Antibiotics induce mitonuclear protein imbalance but fail to inhibit respiration and nutrient activation in pancreatic β-cells
Experimental Cell Research, Vol. 357, Núm. 2, pp. 170-180
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Coordinated activation of mitochondrial respiration & exocytosis mediated by PKC signaling in pancreatic β cells
FASEB Journal, Vol. 31, Núm. 3, pp. 1028-1045
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L-OPA1 regulates mitoflash biogenesis independently from membrane fusion
EMBO Reports, Vol. 18, Núm. 3, pp. 451-463
2014
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NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state
Journal of Biological Chemistry, Vol. 289, Núm. 29, pp. 20377-20385