Ningún efecto favorable de la suplementación de cr (III) en el metabolismo de lípidos en Diabetes tipo 2meta-análisis de ensayos clínicos, simple y doble ciego, controlados con placebo.

  1. San Mauro Martín, Ismael
  2. Ruiz León, Ana María
  3. Garicano Vilar, Elena
  4. Collado Yurrita, Luis
  5. Ciudad Cabañas, María José
  6. de Mateo Silleras, Beatriz
  7. Redondo del Río, María de Paz
  8. Camina Martín, María Alicia
Journal:
Journal of Negative and No Positive Results: JONNPR

ISSN: 2529-850X

Year of publication: 2017

Volume: 2

Issue: 3

Pages: 101-106

Type: Article

DOI: 10.19230/JONNPR.1253 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

More publications in: Journal of Negative and No Positive Results: JONNPR

Abstract

Introduction. Type 2 diabetes mellitus is an important global health issue which prevalence has been increasing in the last years. Many studies have linked chromium supplementation with improvement of type 2 diabetes mellitus.Aim. Perform a meta-analysis of single and double-blind, randomized, placebo controlled trials, where participants diagnosed of type 2 DM or glucose intolerants were supplemented with Cr (III).Methods. Systematic literature search in electronic databases was conducted, using the following search terms: (diabetes) AND (chromium), until July, 2016. Eligible studies were limited to double or single-blind, parallel group, placebo-controlled, randomizedclinical trials, comparing Cr mono or combined supplementation at least for 30 days against placebo, in subjects diagnosed of type 2 DM or with glucose intolerance.Results. Total doses of Cr supplementation and brewer’s yeast ranged from 20 to 1000 μg/day, and duration of supplementation ranged from 30 to 120 days. No statistically significant reduction was found in HDL-C (p=0.63), LDL-C (p=0.53) and TG (p=0.34)compared to placebo; with a weighted average effect size of -0.44 (95% CI: -2.2 to 1.33) mg/dL, -1.43 (95% CI: -5.94 to 3.08) mg/dL and -7.43 (95% CI: -22.67 to 7.82) mg/dL, respectively.Conclusion. Evidence in our study suggests no favourable effects of chromium supplementation on lipid metabolism control in patients with type 2 diabetes. 

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