Transcriptional control of ICPO and its effect on herpes simplex virus-1 replication

  1. Khalique, Hena
Dirigida per:
  1. Filip Lim Director/a

Universitat de defensa: Universidad Autónoma de Madrid

Fecha de defensa: 18 de de juny de 2015

Tribunal:
  1. Enrique Tabares López President/a
  2. David Gómez Míguez Secretari/ària
  3. Jose María Bautista Santa Cruz Vocal
  4. María Teresa Alonso Alonso Vocal

Tipus: Tesi

Teseo: 440119 DIALNET lock_openBiblos-e Archivo editor

Resum

Hsv-1 is among the largest dna viruses investigated for gene transfer and has been engineered as a vector for application in gene therapy. The ability of shv-1 to switch between lytic infection and latency is an attractive property to exploit for hsv.1 vector engineering. The main objective of this study was to analyse the possibility of controlling the lytic-latent transition by manipulating hsv-1 regulatory genes, epecifically icp0.