Transcriptional control of ICPO and its effect on herpes simplex virus-1 replication

  1. Khalique, Hena
Dirixida por:
  1. Filip Lim Director

Universidade de defensa: Universidad Autónoma de Madrid

Fecha de defensa: 18 de xuño de 2015

Tribunal:
  1. Enrique Tabares López Presidente/a
  2. David Gómez Míguez Secretario/a
  3. Jose María Bautista Santa Cruz Vogal
  4. María Teresa Alonso Alonso Vogal

Tipo: Tese

Teseo: 440119 DIALNET lock_openBiblos-e Archivo editor

Resumo

Hsv-1 is among the largest dna viruses investigated for gene transfer and has been engineered as a vector for application in gene therapy. The ability of shv-1 to switch between lytic infection and latency is an attractive property to exploit for hsv.1 vector engineering. The main objective of this study was to analyse the possibility of controlling the lytic-latent transition by manipulating hsv-1 regulatory genes, epecifically icp0.