Transcriptional control of ICPO and its effect on herpes simplex virus-1 replication

  1. Khalique, Hena
Dirigée par:
  1. Filip Lim Directeur/trice

Université de défendre: Universidad Autónoma de Madrid

Fecha de defensa: 18 juin 2015

Jury:
  1. Enrique Tabares López President
  2. David Gómez Míguez Secrétaire
  3. Jose María Bautista Santa Cruz Rapporteur
  4. María Teresa Alonso Alonso Rapporteur

Type: Thèses

Teseo: 440119 DIALNET lock_openBiblos-e Archivo editor

Résumé

Hsv-1 is among the largest dna viruses investigated for gene transfer and has been engineered as a vector for application in gene therapy. The ability of shv-1 to switch between lytic infection and latency is an attractive property to exploit for hsv.1 vector engineering. The main objective of this study was to analyse the possibility of controlling the lytic-latent transition by manipulating hsv-1 regulatory genes, epecifically icp0.