Transcriptional control of ICPO and its effect on herpes simplex virus-1 replication

  1. Khalique, Hena
Zuzendaria:
  1. Filip Lim Zuzendaria

Defentsa unibertsitatea: Universidad Autónoma de Madrid

Fecha de defensa: 2015(e)ko ekaina-(a)k 18

Epaimahaia:
  1. Enrique Tabares López Presidentea
  2. David Gómez Míguez Idazkaria
  3. Jose María Bautista Santa Cruz Kidea
  4. María Teresa Alonso Alonso Kidea

Mota: Tesia

Teseo: 440119 DIALNET lock_openBiblos-e Archivo editor

Laburpena

Hsv-1 is among the largest dna viruses investigated for gene transfer and has been engineered as a vector for application in gene therapy. The ability of shv-1 to switch between lytic infection and latency is an attractive property to exploit for hsv.1 vector engineering. The main objective of this study was to analyse the possibility of controlling the lytic-latent transition by manipulating hsv-1 regulatory genes, epecifically icp0.